Linked Life Data

3400899

Source:http://linkedlifedata.com/resource/pubmed/id/3400899

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-9-1
pubmed:abstractText
Intrauterine sensitization has been reported in animal and clinical studies. One study suggests that the amniotic fluid (AF) IgE level might be useful in predicting infant allergy. We followed for 1 year 83 newborns on whom we had 78 samples of AF, 82 of cord serum (CS), and 83 of maternal serum (MS). All infants were delivered by C-section at term. Amniotic fluid samples were aspirated through the exposed myometrium. Sanguineous specimens were excluded. Amniotic fluid, CS, and MS were tested for total IgE level and IgE RAST to three foods: cow's milk, egg white, and peanut. Data on family medical history, feeding history, and allergy symptoms were collected for 12 months. By 1 year 23% had probable allergy: recurrent wheezing = 8, food related G.I. symptoms = 7, and atopic dermatitis = 4. Allergy in formula-fed infants occurred more often than in those breast-fed for greater than 6 months. IgE in AF was greater than or equal to 0.5 IU/mL in 21/78 (27%); range = 0.5 to 5.9 and geometric mean = 0.76. No correlation was noted between AF total IgE and the appearance of allergy. RAST was equivocally positive in 1.2% AF. Cord serum total IgE was greater than or equal to 0.5 IU/mL in 6/82 (7%); range = 0.5 to 2.6 and geometric mean = 0.72. Allergy appeared in 67% of infants with CS total IgE greater than or equal to 0.5 IU/mL. RAST was negative in all CS samples. In this limited series, AF IgE did not seem to have predictive value of allergy in infancy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0003-4738
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Significance of IgE level in amniotic fluid and cord blood for the prediction of allergy.
pubmed:affiliation
Department of Pediatrics, Louisiana State University Medical School, New Orleans.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't