Linked Life Data

3395316

Source:http://linkedlifedata.com/resource/pubmed/id/3395316

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-8-25
pubmed:abstractText
In the isolated AV junctional preparation of the rabbit heart, the presence of electrotonic influences on impulse formation was investigated. After disconnection of the sinus node, impulse formation started in the junctional area with a mean frequency of 72 beats/min (n = 17), which is about 40% of the sinus rate. Intracellular recordings were obtained to determine pacemaker location and activation sequence in the junctional area. The pacemaker was always located in the area of the lower nodal fibers of the AV node (thus distally from the site of maximal conduction delay) and these fibers had the highest rate of diastolic depolarization. Since it is known that pacemaker fibers are electronically influenced by their neighbouring cells, we investigated whether AV nodal automaticity was influenced by its surrounding tissue. Therefore the AV node was isolated from the atrial tissue and His bundle. This caused an enormous increase in diastolic depolarization rate, especially in the lower nodal fibers, accompanied by a rhythm acceleration to a mean of 137 beats/min. From the findings of the present study it was concluded that under normal conditions impulse formation in the lower nodal fibers of the rabbit AV node is electronically depressed by the connecting myocardium.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0300-8428
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
190-201
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:articleTitle
Evidence for the presence of electrotonic depression of pacemakers in the rabbit atrioventricular node. The effects of uncoupling from the surrounding myocardium.
pubmed:affiliation
Department of Physiology, University of Limburg, Maastricht, The Netherlands.
pubmed:publicationType
Journal Article