Linked Life Data

3335420

Source:http://linkedlifedata.com/resource/pubmed/id/3335420

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-2-25
pubmed:abstractText
The distribution of aminoterminal propeptides of type-III procollagen (indicating the presence of type-III pN-collagen, i.e., type-III collagen molecule with a non-cleaved aminoterminal propeptide), laminin and type-IV collagen was studied by immunohistochemical methods. The results were compared with the distribution of reticular fibres using Gomori's reticulin stain. Lymph nodes from 20 cases of Hodgkin's disease (HD) and 3 spleens affected by nodular sclerosis HD were studied. The reticular fibres stained for all the antigens investigated, the strongest reaction being for pN type-III collagen. Thick fibres stained mainly for type-III pN-collagen, the BM proteins being located in a fragmented rim on the surface. The distribution and composition of fibres was similar in both nodal and extranodal infiltrations. The morphological alterations noted in the fibres comprised (1) compression between nodules in the nodular type of lymphocyte-predominant HD, and (2) fragmentation, present in collections of histiocytes in lymphocyte-predominant HD. BM proteins and type-III pN-collagen were present in the walls of the sinuses and vessels. The marginal sinuses were often partially spared in spite of extracapsular invasion. Our results suggest that laminin, type-IV collagen and type-III pN-collagen are important components of reticular fibres in HD and that the composition of the fibres is similar to that seen in the normal lymph node.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0020-7136
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
52-8
pubmed:dateRevised
2007-7-24
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
An immunohistochemical study of laminin, type-IV collagen and type-III pN-collagen with relation to reticular fibres in Hodgkin's disease.
pubmed:affiliation
Department of Pathology, University of Oulu, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't