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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
|
pubmed:dateCreated |
1988-11-7
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pubmed:abstractText |
Intravenous infusion of secretin in a dose of 0.05 CU/kg/hr inhibited pentagastrin-stimulated (100 ng/kg/hr) acid secretion by 42% (P less than 0.05) abd meal-stimulated (10% peptone, pH 5.5) acid secretion by 33% (P less than 0.05) in 10 healthy subjects. Median serum gastrin concentration during peptone stimulation was reduced by 24% (P less than 0.05) during secretin infusion. Median plasma secretin concentrations were 6.0 and 5.2 pmol/liter, respectively. Since these secretin concentrations are of the same magnitude as those seen after duodenal acidification, it is concluded that secretin may participate in the physiological inhibition of gastric acid secretion.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
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pubmed:issn |
0163-2116
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1277-81
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3168699-Adult,
pubmed-meshheading:3168699-Eating,
pubmed-meshheading:3168699-Female,
pubmed-meshheading:3168699-Gastric Acid,
pubmed-meshheading:3168699-Humans,
pubmed-meshheading:3168699-Hydrogen-Ion Concentration,
pubmed-meshheading:3168699-Male,
pubmed-meshheading:3168699-Pentagastrin,
pubmed-meshheading:3168699-Peptones,
pubmed-meshheading:3168699-Secretin
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pubmed:year |
1988
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pubmed:articleTitle |
Effect of low-dose exogenous secretin on pentagastrin- and meal-stimulated gastric acid secretion in humans.
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pubmed:affiliation |
Department of Surgery D, Glostrup Hospital, University of Copenhagen, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|