Linked Life Data

3114770

Source:http://linkedlifedata.com/resource/pubmed/id/3114770

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1987-10-14
pubmed:abstractText
Five adenosine analogues resistant to adenosine deaminase were analyzed for their effects on the proliferation on cultured Vero cells. Cells were exposed for 48 hr to various concentrations of 1-deazaadenosine (c1Ado), 3-deazaadenosine (c3Ado), 7-deazaadenosine (c7Ado), 1,3-dideazaadenosine (c1,3Ado) or 1,7-dideazaadenosine (c1,7Ado) and then counted with a hemocytometer. Results indicate that 1) whereas c7Ado produced a marked decrease in cell growth, c3Ado was toxic only at the highest concentration tested (30 microM), 2) c1Ado and c1,7Ado did not affect cell replication and 3) c1,3Ado produced a significant stimulation of cell proliferation. Further studies have suggested that none of the compounds tested is incorporated in the DNA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0031-6989
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
359-66
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
The effect of deazaadenosine analogues on the proliferation rate of cultured Vero cells.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't