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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1986-6-27
|
| pubmed:abstractText |
Using the in vitro hippocampal slice preparation, we studied the electrophysiological properties of pyramidal cells in tissue that was 'preincubated' (2-6 h in a large, static volume of oxygenated bathing medium) before being placed in an interface chamber for study. Striking differences were found in 'preincubated' vs 'non-preincubated' CA3 cells. The preincubated cells had more negative resting potentials, higher input resistance, lower threshold for stimulus-evoked burst discharge and larger hyperpolarizing afterpotentials. Cells in the preincubated CA3 region were also more likely to show spontaneous synchronized burst discharge, but were relatively resistant to hypoxia-induced spreading depression. CA1 cells were less dramatically affected by preincubation, showing little difference from their non-preincubated counterparts. Possible mechanisms involved in the CA3 preincubation effect, including glial buffering alterations and changes in Na+, K+-ATPase activity, are discussed.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
2
|
| pubmed:volume |
370
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
44-53
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3011193-Animals,
pubmed-meshheading:3011193-Cell Membrane,
pubmed-meshheading:3011193-Electric Conductivity,
pubmed-meshheading:3011193-Evoked Potentials,
pubmed-meshheading:3011193-Hippocampus,
pubmed-meshheading:3011193-Hypoxia, Brain,
pubmed-meshheading:3011193-Male,
pubmed-meshheading:3011193-Membrane Potentials,
pubmed-meshheading:3011193-Neural Inhibition,
pubmed-meshheading:3011193-Rats,
pubmed-meshheading:3011193-Rats, Inbred Strains,
pubmed-meshheading:3011193-Synaptic Transmission
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Effects of tissue preincubation and hypoxia on CA3 hippocampal neurons in the in vitro slice preparation.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|