| pubmed-article:3002635 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3002635 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:3002635 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:3002635 | lifeskim:mentions | umls-concept:C0012920 | lld:lifeskim |
| pubmed-article:3002635 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:3002635 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3002635 | pubmed:dateCreated | 1986-3-14 | lld:pubmed |
| pubmed-article:3002635 | pubmed:abstractText | The in vivo distribution of topoisomerase I on specific DNA sequences is determined at high resolution in Drosophila cells using a photo-crosslinking method. Topoisomerase I-DNA adducts are generated by irradiation of intact cells with UV light and then purified by immunoprecipitation with antibody to topoisomerase I. Analyses of the DNA sequences crosslinked to topoisomerase I by blot-hybridization with appropriate DNA probes indicate that topoisomerase I is concentrated on transcribed regions and not on nontranscribed flanking sequences. Like RNA polymerase II, topoisomerase I is recruited to heat-shock genes during the heat-shock response. However, topoisomerase I and RNA polymerase II can interact independently with the transcribed region because different ratios of topoisomerase I and RNA polymerase II are crosslinked to the highly transcribed hsp70 gene and the moderately transcribed copia genes. We hypothesize that topoisomerase I allows topological changes in DNA that are required for transcription. | lld:pubmed |
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| pubmed-article:3002635 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3002635 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3002635 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3002635 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3002635 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3002635 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3002635 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:3002635 | pubmed:author | pubmed-author:GayM JMJ | lld:pubmed |
| pubmed-article:3002635 | pubmed:author | pubmed-author:WangJ CJC | lld:pubmed |
| pubmed-article:3002635 | pubmed:author | pubmed-author:PflugfelderGG | lld:pubmed |
| pubmed-article:3002635 | pubmed:author | pubmed-author:GilmourD SDS | lld:pubmed |
| pubmed-article:3002635 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3002635 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:3002635 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:3002635 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3002635 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3002635 | pubmed:pagination | 401-7 | lld:pubmed |
| pubmed-article:3002635 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:3002635 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3002635 | pubmed:articleTitle | Topoisomerase I interacts with transcribed regions in Drosophila cells. | lld:pubmed |
| pubmed-article:3002635 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3002635 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3002635 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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