rdf:type |
|
lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0008976,
umls-concept:C0013089,
umls-concept:C0024109,
umls-concept:C0028096,
umls-concept:C0034656,
umls-concept:C0042679,
umls-concept:C0182936,
umls-concept:C0449207,
umls-concept:C0559546,
umls-concept:C1521750
|
pubmed:issue |
9
|
pubmed:dateCreated |
1985-10-7
|
pubmed:abstractText |
From April 1981 to February 1983, 116 untreated patients (ECOG PS 0-3) with histologically or cytologically proven small cell lung cancer were randomly allocated to chemotherapy regimen using CPA.ACNU.VCR (CNV, n = 64) or ADR.ACNU.VCR (ANV, n = 52). The objective tumor response was 29.7% (19/53) for the CNV regimen and 48.1% (25/48) for the ANV regimen, but there was no statistically significant difference in these groups. Median survival time was 22.9 w for the CNV regimen (n = 64) and 42.4 w for the ANV (n = 52) regimen. The survival rate was statistically significantly higher for the ANV regimen compared to that of the CNV regimen (P greater than 5%). The toxicity showed no difference between these groups. Addition of ADR to ACNU + VCR was effective, but addition of CPA to these two drugs was not effective.
|
pubmed:language |
jpn
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0385-0684
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
12
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1844-9
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2994577-Aged,
pubmed-meshheading:2994577-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:2994577-Carcinoma, Small Cell,
pubmed-meshheading:2994577-Clinical Trials as Topic,
pubmed-meshheading:2994577-Cyclophosphamide,
pubmed-meshheading:2994577-Doxorubicin,
pubmed-meshheading:2994577-Drug Administration Schedule,
pubmed-meshheading:2994577-Female,
pubmed-meshheading:2994577-Humans,
pubmed-meshheading:2994577-Lung Neoplasms,
pubmed-meshheading:2994577-Male,
pubmed-meshheading:2994577-Middle Aged,
pubmed-meshheading:2994577-Nimustine,
pubmed-meshheading:2994577-Nitrosourea Compounds,
pubmed-meshheading:2994577-Prognosis,
pubmed-meshheading:2994577-Random Allocation,
pubmed-meshheading:2994577-Vincristine
|
pubmed:year |
1985
|
pubmed:articleTitle |
[A randomized trial of 3-drug combination chemotherapy in small cell lung cancer--CPA/ACNU/VCR vs ADR/ACNU/VCR].
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
English Abstract,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|