| pubmed-article:2925247 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2925247 | lifeskim:mentions | umls-concept:C0175677 | lld:lifeskim |
| pubmed-article:2925247 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
| pubmed-article:2925247 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:2925247 | lifeskim:mentions | umls-concept:C2709248 | lld:lifeskim |
| pubmed-article:2925247 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:2925247 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2925247 | pubmed:dateCreated | 1989-5-5 | lld:pubmed |
| pubmed-article:2925247 | pubmed:abstractText | Tumor necrosis factor alpha (TNF-alpha) mediates components of the acute-phase response, stimulates granulocyte metabolism, and induces endothelial cell surface changes. We studied whether human recombinant TNF-alpha (rTNF-alpha) could increase pulmonary edema formation and pulmonary vascular permeability. Rabbits preinfused with 125I-albumin were administered rTNF-alpha or saline. Animals were sacrificed, and lung wet/dry weight ratios as well as bronchoalveolar lavage fluid and plasma 125I activities were determined. rTNF-alpha increased lung wet/dry weight ratios by 151% (P less than 0.02) and bronchoalveolar lavage fluid/plasma 125I activity ratios by 376% (P less than 0.01) compared with values for saline controls. Electron microscopy of lung sections demonstrated endothelial injury, perivascular edema, and extravasation of an ultrastructural permeability tracer. To demonstrate that rTNF-alpha could directly increase pulmonary vascular endothelial permeability in vitro, we studied albumin transfer across cultured porcine pulmonary artery endothelial cell monolayers. rTNF-alpha induced time-dependent dose-response increments in transendothelial albumin flux in the absence of granulocyte effector cells. These observations suggest that rTNF-alpha can provoke acute pulmonary vascular endothelial injury in vivo as well as in vitro. | lld:pubmed |
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| pubmed-article:2925247 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2925247 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2925247 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2925247 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2925247 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:2925247 | pubmed:author | pubmed-author:JayMM | lld:pubmed |
| pubmed-article:2925247 | pubmed:author | pubmed-author:YonedaKK | lld:pubmed |
| pubmed-article:2925247 | pubmed:author | pubmed-author:McClainC JCJ | lld:pubmed |
| pubmed-article:2925247 | pubmed:author | pubmed-author:HennigBB | lld:pubmed |
| pubmed-article:2925247 | pubmed:author | pubmed-author:GoldblumS ESE | lld:pubmed |
| pubmed-article:2925247 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2925247 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:2925247 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2925247 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2925247 | pubmed:pagination | 1218-26 | lld:pubmed |
| pubmed-article:2925247 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2925247 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2925247 | pubmed:articleTitle | Tumor necrosis factor alpha-induced pulmonary vascular endothelial injury. | lld:pubmed |
| pubmed-article:2925247 | pubmed:affiliation | Department of Medicine, Veterans Administration Medical Center, Baltimore, Maryland. | lld:pubmed |
| pubmed-article:2925247 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2925247 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2925247 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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