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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1989-5-5
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pubmed:abstractText |
Tumor necrosis factor alpha (TNF-alpha) mediates components of the acute-phase response, stimulates granulocyte metabolism, and induces endothelial cell surface changes. We studied whether human recombinant TNF-alpha (rTNF-alpha) could increase pulmonary edema formation and pulmonary vascular permeability. Rabbits preinfused with 125I-albumin were administered rTNF-alpha or saline. Animals were sacrificed, and lung wet/dry weight ratios as well as bronchoalveolar lavage fluid and plasma 125I activities were determined. rTNF-alpha increased lung wet/dry weight ratios by 151% (P less than 0.02) and bronchoalveolar lavage fluid/plasma 125I activity ratios by 376% (P less than 0.01) compared with values for saline controls. Electron microscopy of lung sections demonstrated endothelial injury, perivascular edema, and extravasation of an ultrastructural permeability tracer. To demonstrate that rTNF-alpha could directly increase pulmonary vascular endothelial permeability in vitro, we studied albumin transfer across cultured porcine pulmonary artery endothelial cell monolayers. rTNF-alpha induced time-dependent dose-response increments in transendothelial albumin flux in the absence of granulocyte effector cells. These observations suggest that rTNF-alpha can provoke acute pulmonary vascular endothelial injury in vivo as well as in vitro.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-1103152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-2421578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-2429991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-2835680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-2999236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-2999289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3001018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3009619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3011946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3028403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3031000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3059859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3093587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3100615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3128274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3258319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3261716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3458948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3485132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3486903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3486936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3487091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3489939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3494060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3494061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3500942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3526909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3753996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3764421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3772113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3866246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3871770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3895437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3926894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-3980730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-4812036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-4888307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-4933764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-6392892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-6477300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-6953825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-7038493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-7073114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2925247-7298850
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1218-26
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2925247-Animals,
pubmed-meshheading:2925247-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:2925247-Capillary Permeability,
pubmed-meshheading:2925247-Cells, Cultured,
pubmed-meshheading:2925247-Endothelium, Vascular,
pubmed-meshheading:2925247-Granulocytes,
pubmed-meshheading:2925247-Humans,
pubmed-meshheading:2925247-Leukocyte Count,
pubmed-meshheading:2925247-Lung,
pubmed-meshheading:2925247-Pulmonary Edema,
pubmed-meshheading:2925247-Rabbits,
pubmed-meshheading:2925247-Recombinant Proteins,
pubmed-meshheading:2925247-Swine,
pubmed-meshheading:2925247-Tumor Necrosis Factor-alpha
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pubmed:year |
1989
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pubmed:articleTitle |
Tumor necrosis factor alpha-induced pulmonary vascular endothelial injury.
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pubmed:affiliation |
Department of Medicine, Veterans Administration Medical Center, Baltimore, Maryland.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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