rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4858
|
pubmed:dateCreated |
1988-7-14
|
pubmed:abstractText |
The proliferating cell nuclear antigen (PCNA or cyclin) is a nuclear protein recently identified as a cofactor of DNA polymerase delta. When exponentially growing Balb/c3T3 cells are exposed to antisense oligodeoxynucleotides to PCNA, both DNA synthesis and mitosis are completely suppressed. A corresponding sense oligodeoxynucleotide has no inhibitory effects. These experiments indicate that PCNA (cyclin) is important in cellular DNA synthesis and in cell cycle progression.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0036-8075
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
10
|
pubmed:volume |
240
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1544-6
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:2897717-Animals,
pubmed-meshheading:2897717-Autoantigens,
pubmed-meshheading:2897717-Base Sequence,
pubmed-meshheading:2897717-Cell Division,
pubmed-meshheading:2897717-Cells, Cultured,
pubmed-meshheading:2897717-Codon,
pubmed-meshheading:2897717-DNA Replication,
pubmed-meshheading:2897717-Kinetics,
pubmed-meshheading:2897717-Mice,
pubmed-meshheading:2897717-Mice, Inbred BALB C,
pubmed-meshheading:2897717-Mitosis,
pubmed-meshheading:2897717-Molecular Sequence Data,
pubmed-meshheading:2897717-Nuclear Proteins,
pubmed-meshheading:2897717-Oligodeoxyribonucleotides,
pubmed-meshheading:2897717-Proliferating Cell Nuclear Antigen
|
pubmed:year |
1988
|
pubmed:articleTitle |
Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin.
|
pubmed:affiliation |
Department of Pathology, Temple University Medical School, Philadelphia, PA 19140.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|