Linked Life Data

2890434

Source:http://linkedlifedata.com/resource/pubmed/id/2890434

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-1-7
pubmed:abstractText
The term transforming growth factor (TGF) has been applied to peptides that have the ability to confer the transformed phenotype on untransformed fibroblastic indicator cells in vitro. Peptides representing two distinct classes of TGFs have been purified to homogeneity. Type alpha and type beta TGFs are distinguished both chemically by their unique amino acid sequences and biologically by their different activities on cells. Type alpha TGFs are single chain peptides of 50-53 amino acids cross-linked by three disulphide bonds. They have strong homology to epidermal growth factor with which they compete for receptor binding. Type beta TGFs have a homodimeric structure comprised of two chains of 112 amino acids, each containing nine cysteine residues; TGF beta binds to a unique cell surface receptor. Type alpha TGFs are usually mitogenic for fibroblasts, whereas type beta TGFs have bifunctional effects on cell growth and can either stimulate or inhibit growth of the same cells, depending on conditions. The interactions of type alpha and beta TGFs can be either synergistic or antagonistic. Though the development of peptide antagonists to type alpha TGFs may have therapeutic potential for the treatment of malignancy, type beta TGFs may inhibit tumorigenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0261-2429
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
683-705
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Transforming growth factors.
pubmed:affiliation
Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892.
pubmed:publicationType
Journal Article, Review