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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0023473,
umls-concept:C0029016,
umls-concept:C0040715,
umls-concept:C0072480,
umls-concept:C0599718,
umls-concept:C0599813,
umls-concept:C0599893,
umls-concept:C0751995,
umls-concept:C1522702,
umls-concept:C1533148,
umls-concept:C1552913,
umls-concept:C1704928,
umls-concept:C1705597
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|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1989-8-4
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|
pubmed:abstractText |
In a case of CML with a variant Philadelphia translocation (Ph1 or Ph) t(22;22) (q11;q13) in bone marrow cells and unstimulated peripheral blood cells, no cytogenetically detectable involvement of chromosome 9 was observed. Southern blot experiments using probes specific for bcr and c-sis however revealed rearrangement of the bcr, but not of PDGFB (c-sis) gene. Northern blot analysis of bone marrow RNA showed a very weak signal with the c-sis probe, while in a lymph-node biopsy PDGFB m-RNA could not be detected. Chromosomal in situ hybridization gave evidence for translocation of c-abl from chromosome 9 to Ph and of PDGFB from chromosome 22 to chromosome 9, as the result of a threefold translocation t(9;22;22).
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-5242
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
279-85
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2660925-Bone Marrow,
pubmed-meshheading:2660925-Chromosomes, Human, Pair 22,
pubmed-meshheading:2660925-Chromosomes, Human, Pair 9,
pubmed-meshheading:2660925-DNA,
pubmed-meshheading:2660925-Growth Substances,
pubmed-meshheading:2660925-Humans,
pubmed-meshheading:2660925-Karyotyping,
pubmed-meshheading:2660925-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:2660925-Lymph Nodes,
pubmed-meshheading:2660925-Male,
pubmed-meshheading:2660925-Middle Aged,
pubmed-meshheading:2660925-Nucleic Acid Hybridization,
pubmed-meshheading:2660925-Philadelphia Chromosome,
pubmed-meshheading:2660925-Platelet-Derived Growth Factor,
pubmed-meshheading:2660925-Proto-Oncogene Proteins,
pubmed-meshheading:2660925-Proto-Oncogene Proteins c-abl,
pubmed-meshheading:2660925-Proto-Oncogene Proteins c-sis,
pubmed-meshheading:2660925-Proto-Oncogenes,
pubmed-meshheading:2660925-RNA, Messenger,
pubmed-meshheading:2660925-Translocation, Genetic
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|
pubmed:year |
1989
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|
pubmed:articleTitle |
Translocation of c-abl oncogene and PDGFB (c-sis) gene in a case of CML with 46,XY, t(22;22).
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pubmed:affiliation |
Institut für Humangenetik, Medizinische Universität zu Lübeck, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|
