Linked Life Data

2632227

Source:http://linkedlifedata.com/resource/pubmed/id/2632227

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-5-21
pubmed:abstractText
The identities of the second through ninth abdominal segments of Drosophila are specified by two genes of the bithorax complex (BX-C), abdominal-A (abd-A) and Abdominal B (Abd-B). The correct deployment of these two genes requires an extensive region (the iab region) located between the two protein-coding transcription units. We show here that one iab mutation affects the pattern of expression of Abd-B. We also show that most or all of the DNA in this regulatory iab region is transcribed. In blastoderm stage embryos we can define three distinct domains within the iab DNA, each transcribed in a region that extends from a characteristic anterior limit to the posterior end of the segmented part of the embryo. The anterior limits of expression for the three regions are colinear with the sequence of the domains on the chromosome, and lie at about two-segment intervals. We suggest that these early transcription patterns reflect the initial activation of the BX-C.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0950-1991
pubmed:author
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
321-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Spatially ordered transcription of regulatory DNA in the bithorax complex of Drosophila.
pubmed:affiliation
Department of Genetics, University of Cambridge, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't