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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1990-3-8
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pubmed:abstractText |
The examination of pair-rule gene expression in wild-type and segmentation mutant embryos has identified many, but not necessarily all, of the elements of the regulatory system that establish their periodic patterns. Here we have conducted a new type of search for previously unknown regulators of these genes by examining pair-rule gene expression in blastoderm embryos lacking parts of or entire chromosomes. This method has the advantage of direct inspection of abnormal pair-rule gene patterns without relying upon mutagenesis or interpretation of larval phenotypes for the identification of segmentation genes. From these experiments we conclude that: (i) most zygotically required regulators of the fushi tarazu (ftz), even-skipped (eve) and hairy (h) pair-rule genes have been identified, except for one or more loci we have uncovered on chromosome arm 2L; (ii) the repression of the ftz and eve genes in the anterior third of the embryo is under maternal, not zygotic control; and (iii) there are no general zygotically required activators of pair-rule gene expression. The results suggest that the molecular basis of pair-rule gene regulation can be pursued with greater confidence now that most key trans-acting factors are already in hand.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
pubmed:issn |
0950-1991
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
663-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2612384-Animals,
pubmed-meshheading:2612384-Chromosome Deletion,
pubmed-meshheading:2612384-Chromosome Mapping,
pubmed-meshheading:2612384-Crosses, Genetic,
pubmed-meshheading:2612384-Drosophila,
pubmed-meshheading:2612384-Genes, Regulator,
pubmed-meshheading:2612384-Mutation,
pubmed-meshheading:2612384-Zygote
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pubmed:year |
1989
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pubmed:articleTitle |
The zygotic control of Drosophila pair-rule gene expression. I. A search for new pair-rule regulatory loci.
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pubmed:affiliation |
Laboratory of Molecular Biology, University of Wisconsin, Madison 53706.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|