Linked Life Data

2591688

Source:http://linkedlifedata.com/resource/pubmed/id/2591688

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1990-1-12
pubmed:abstractText
We have studied the effects of acetorphan, an inhibitor of enkephalinase, on the electrical activity of human rectum. Acetorphan activated the rectum of healthy volunteers by inducing bursts of spike potentials, this activation might become cyclical. In contrast, this drug failed to modify the motility of the aganglionic portion of the rectum in one case of Hirschsprung's disease, indicating that the effect of acetorphan involves the intramural plexuses. Activation of the rectum persisted in spite of the blockade of the cholinergic excitatory pathways by atropine, which confirms the existence of an excitatory non-cholinergic mechanism for the rectum. Our results also suggest that the neurotransmitter responsible for this effect is continuously released by the nervous structures implicated in the control of rectal motility. Immunohistochemical data show that the rectum is supplied by a rich enkephalinergic innervation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0399-8320
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
799-803
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Non-cholinergic neural excitation of the human rectum induced by acetorphan, an inhibitor of enkephalinase.
pubmed:affiliation
Service d'Hépato Gastroentérologie, Hôpital Nord, Marseille.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't