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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1989-9-12
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pubmed:abstractText |
N-myc proto-oncogene rearrangement was found in three out of six AKR murine T-cell lymphomas induced by the highly oncogenic MCF 247 MuLV. Molecular analyses showed that structural modification of the proto-oncogene in all three lymphomas was in the consequence of MCF 247 proviral integration within the gene III exon. All integrated proviruses have the same transcriptional orientation as the N-myc gene. As a consequence of proviral insertion, the N-myc gene becomes transcriptionally active, producing an abnormal mRNA. These findings suggest a possible causative role of such an integrative event in murine T-cell lymphomagenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0950-9232
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1009-14
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2548143-Amino Acid Sequence,
pubmed-meshheading:2548143-Animals,
pubmed-meshheading:2548143-Base Sequence,
pubmed-meshheading:2548143-Cell Transformation, Viral,
pubmed-meshheading:2548143-DNA, Neoplasm,
pubmed-meshheading:2548143-Gene Rearrangement,
pubmed-meshheading:2548143-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:2548143-Leukemia Virus, Murine,
pubmed-meshheading:2548143-Mice,
pubmed-meshheading:2548143-Molecular Sequence Data,
pubmed-meshheading:2548143-Proto-Oncogene Proteins,
pubmed-meshheading:2548143-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:2548143-Proto-Oncogenes,
pubmed-meshheading:2548143-RNA, Messenger,
pubmed-meshheading:2548143-RNA, Neoplasm,
pubmed-meshheading:2548143-Recombination, Genetic,
pubmed-meshheading:2548143-Restriction Mapping,
pubmed-meshheading:2548143-T-Lymphocytes,
pubmed-meshheading:2548143-Transcription, Genetic
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pubmed:year |
1989
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pubmed:articleTitle |
N-myc activation by proviral insertion in MCF 247-induced murine T-cell lymphomas.
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pubmed:affiliation |
Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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