MYCN gene

Source:http://linkedlifedata.com/resource/umls/id/C0812287

NCI: This gene is involved in transcriptional regulation and amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.,NCI: Human Oncogene NMYC is a mutated variant of NMYC Gene (MYC Family), which encodes two nuclear N-MYC Proteins from the same mRNA; both are phosphorylated, exceptionally unstable and bind to single- and double-stranded DNA. N-MYC is a likely heterodimeric bZIP transcription factor with MAX; efficient DNA binding requires dimerization with another bHLH protein. NMYC amplification is associated with oncogenic transformation. Oncogene NMYC disrupts normal cell function.

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