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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
1989-8-16
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pubmed:abstractText |
The Q genes of phages lambda and 82 encode transcription antiterminators that are active in vitro in a purified transcription system. Transcription termination is thought to involve two distinct steps: pausing of the transcription complex at the terminator and release of enzyme and RNA; either or both steps might be inhibited by Q protein. We show that Q-modified RNA polymerase pauses much less efficiently than does unmodified enzyme at the natural pause sites of a rho-dependent terminator as well as at other pause sites. This changed behavior can account for the termination properties of Q-modified RNA polymerase and reflects a fundamental alteration of the elongation properties of the enzyme.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-1098042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-1101952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-2436219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-2445490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-2445491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-2449971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-2960589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-2965813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-2981220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-2990726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-3040263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-3527045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-3624233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-371677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-4365581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-6159577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-6199039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-6206069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-6215986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-6216477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-6217346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-6223929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-6231216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-6246357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-6308007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-634366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-6345540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-6452899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-6758952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526335-7009597
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5301-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2526335-Bacteriophage lambda,
pubmed-meshheading:2526335-Coliphages,
pubmed-meshheading:2526335-DNA-Directed RNA Polymerases,
pubmed-meshheading:2526335-Escherichia coli,
pubmed-meshheading:2526335-Genes,
pubmed-meshheading:2526335-Genes, Regulator,
pubmed-meshheading:2526335-Genes, Viral,
pubmed-meshheading:2526335-Rho Factor,
pubmed-meshheading:2526335-Suppression, Genetic,
pubmed-meshheading:2526335-Templates, Genetic,
pubmed-meshheading:2526335-Terminator Regions, Genetic,
pubmed-meshheading:2526335-Transcription, Genetic,
pubmed-meshheading:2526335-Transcription Factors,
pubmed-meshheading:2526335-Viral Proteins
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pubmed:year |
1989
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pubmed:articleTitle |
Gene Q antiterminator proteins of Escherichia coli phages 82 and lambda suppress pausing by RNA polymerase at a rho-dependent terminator and at other sites.
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pubmed:affiliation |
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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