Linked Life Data

2471664

Source:http://linkedlifedata.com/resource/pubmed/id/2471664

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-7-24
pubmed:abstractText
High resolution microscopy in conjunction with colloidal gold-labeled insulin has been used to provide evidence that insulin is internalized by preimplantation mouse embryos by means of receptor-mediated endocytosis and concentration in coated pits. In addition, immunocytochemical analyses at the blastocyst stage, using gold-labeled anti-insulin receptor immunoglobulin (IgG) have confirmed the expression of insulin receptors on all cells of the embryo, including the inner cell mass. Immunocytochemical studies using gold-labeled anti-insulin IgG have provided evidence that the insulin internalized by the embryo is maternally derived. Functional studies show that incubating embryos in physiological levels of insulin results in increased synthesis of RNA and DNA. We conclude that insulin may play a role in early mammalian development, although the precise function of this hormone remains to be defined.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
48-58
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Preimplantation mouse embryos internalize maternal insulin via receptor-mediated endocytosis: pattern of uptake and functional correlations.
pubmed:affiliation
Department of Obstetrics and Gynecology, Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.