Linked Life Data

2461698

Source:http://linkedlifedata.com/resource/pubmed/id/2461698

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-12-29
pubmed:abstractText
Two neutralizing monoclonal antibodies (MCAs), R63 and B69, were used in antigen-capture enzyme immunoassays to verify the presence of infectious bursal disease virus (IBDV) in infected bursal tissues. The intra-serotype-common neutralization site defined by the R63 MCA was present on all IBDV isolates and laboratory strains tested. However, the neutralization site defined by the B69 MCA was found on only classic or older IBDV strains; it was not found on recently isolated variants of IBDV or on a majority of recent field viruses examined. The data suggest that a major antigenic shift in IBDV has occurred in the field and that this shift involves, at a minimum, the deletion or alteration of one of two neutralization sites previously found on classic IBDV strains.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0005-2086
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
535-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Differentiation of infectious bursal disease viruses directly from infected tissues with neutralizing monoclonal antibodies: evidence of a major antigenic shift in recent field isolates.
pubmed:affiliation
Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College, Park 20742.
pubmed:publicationType
Journal Article, Comparative Study