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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1990-10-18
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pubmed:abstractText |
Mutagen-sensitive strains that identify 16 different Drosophila genes have been screened for alterations in DNA metabolic enzymes. A characteristic defect in an acid-active deoxyribonuclease was observed in strains carrying the six available mutant alleles of the mus308 gene. Since that enzyme is detected at normal levels in a mutant strain that is deficient in the previously identified enzymes DNase 1 and DNase 2, it represents a new Drosophila nuclease that is designated Nuclease 3. The mus308 mutants were originally distinguished from all other mutagen-sensitive mutants of Drosophila because they exhibit hypersensitivity to the DNA cross-linking agent nitrogen mustard without expressing a concurrent sensitivity to the monofunctional agent methyl methanesulfonate. Further observations of hypersensitivity to the mutagens trimethylpsoralen, diepoxybutane and cis-platinum now establish a more general sensitivity of these mutants to agents capable of generating DNA cross-links. In spite of the hypersensitivity of the mus308 mutants to DNA cross-linking agents, the initial incision step of DNA cross-link repair is normal in mus308 cells as assayed by the alkaline elution procedure. The Drosophila mus308 mutants show promise of providing a useful model for analogous defects in other organisms including man.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-109079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-187527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-2411210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-3093856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-3308924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-3349473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-3412362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-3534882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-3587254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-3670329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-3762562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-3762563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-565680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-6776988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-6783028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-6795083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-6795495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-6799745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-6818427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-7009316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2397884-889829
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0016-6731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
813-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2397884-Animals,
pubmed-meshheading:2397884-Cross-Linking Reagents,
pubmed-meshheading:2397884-DNA,
pubmed-meshheading:2397884-DNA Repair,
pubmed-meshheading:2397884-Deoxyribonucleases,
pubmed-meshheading:2397884-Drosophila,
pubmed-meshheading:2397884-Ficusin,
pubmed-meshheading:2397884-Genes,
pubmed-meshheading:2397884-Mechlorethamine,
pubmed-meshheading:2397884-Mutagens,
pubmed-meshheading:2397884-Mutation
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pubmed:year |
1990
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pubmed:articleTitle |
mus308 mutants of Drosophila exhibit hypersensitivity to DNA cross-linking agents and are defective in a deoxyribonuclease.
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pubmed:affiliation |
Department of Genetics, University of California, Davis 95616.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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