Linked Life Data

2370917

Source:http://linkedlifedata.com/resource/pubmed/id/2370917

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-8-23
pubmed:abstractText
Because of the deep evolutionary roots which macrophages and their products have, it should be possible to relate effects of the biological response modifier TNF observed in cancer patients with those determined in animal species. We have tested this hypothesis both with regard to antitumor efficacy and unwanted side-effects in murine tumor models. In the intramuscularly (i.m.) transplanted B16 melanoma, TNF had both after intratumoral (i.t.) and intravenous (i.v.) administration (qd 7-11, 14-17) a significant and dose-dependent effect on tumor growth. This effect was transitory and led only to a moderate increase in survival time of the animals. This correlates well with the also unsatisfactory clinical antineoplastic activity of TNF. From the measurement of body weight reduction, WBC counts, platelets, recalcification time, transaminases and body temperature in tumor bearing mice it can be concluded that there are close similarities to the side-effects observed in patients, although the level and/or time course of the noticed changes were differently expressed. In principle, it seems possible to predict clinical effects of biological response modifiers in animal experiments even if not all mechanisms are clearly understood.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-2685
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
301-15
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Determination of antineoplastic activity and toxicity of tumor necrosis factor (TNF) in animal experiments. Correlation to clinical findings.
pubmed:affiliation
Academy of Sciences of GDR, Central Institute of Cancer Research, Berlin-Buch.
pubmed:publicationType
Journal Article