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rdf:type |
|
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lifeskim:mentions |
|
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pubmed:issue |
3
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pubmed:dateCreated |
1990-5-7
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pubmed:abstractText |
Parathyroid hormone related peptide (PTHrP) has been implicated in the cause of the hypercalcemia associated with a number of malignant tumours. The data presented here suggests that PTHrP (in addition to its known role of mediating hypercalcemia) may be involved in the autocrine regulation of growth of some tumours. Polyclonal PTHrP antiserum almost totally inhibited the growth of a human renal cell carcinoma cell line, known to secrete PTHrP, in vitro and growth was significantly inhibited by the competitive PTH antagonist PTH (3-34)NH2.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-291X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
30
|
|
pubmed:volume |
167
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1134-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2322262-Carcinoma, Renal Cell,
pubmed-meshheading:2322262-Cell Division,
pubmed-meshheading:2322262-Dose-Response Relationship, Drug,
pubmed-meshheading:2322262-Humans,
pubmed-meshheading:2322262-Immune Sera,
pubmed-meshheading:2322262-Kidney Neoplasms,
pubmed-meshheading:2322262-Parathyroid Hormone,
pubmed-meshheading:2322262-Parathyroid Hormone-Related Protein,
pubmed-meshheading:2322262-Peptide Fragments,
pubmed-meshheading:2322262-Proteins,
pubmed-meshheading:2322262-Structure-Activity Relationship,
pubmed-meshheading:2322262-Tumor Cells, Cultured
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pubmed:year |
1990
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|
pubmed:articleTitle |
Parathyroid hormone related peptide can function as an autocrine growth factor in human renal cell carcinoma.
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pubmed:affiliation |
Division of Biomedical Sciences, Kings College, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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