Linked Life Data

2177724

Source:http://linkedlifedata.com/resource/pubmed/id/2177724

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-3-13
pubmed:abstractText
BALB/c mice that are infected with reovirus Type 1 develop thyroiditis. Viral antigens were seen in the cytoplasm of epithelial cells but not in the surrounding colloidal space of the thyroid. Examination of sera from the infected mice revealed autoantibodies that, by immunofluorescence, reacted with second antigens in the colloid (ground-glass staining pattern) and thyroglobulin (puffy staining pattern). An enzyme-linked immunosorbent assay designed to identify the reactive antigens showed the autoantibodies to direct against thyroglobulin. Synthetic serum thymic factor (FTS) suppressed autoantibody production to the thyroid after reovirus Type 1 infection. Reovirus Type 3, in contrast to reovirus Type 1, did not induce autoantibodies to react against thyroglobulin. By the use of recombinants between reovirus Type 1 and Type 3, the segment of the reovirus genome responsible for the induction of autoantibodies to thyroglobulin was identified. Virus containing the S1 genome segment from reovirus Type 1, which codes the sigma 1 polypeptide (i.e. haemagglutinin), infected epithelial cells in the thyroid and induced autoantibodies against the thyroglobulin. However, virus containing the S1 gene segment from reovirus Type 3 failed to infect cells in the thyroid and did not induce autoantibodies against thyroglobulin. In this study, reovirus Type 1 induces thyroiditis and autoimmunity, and the S1 gene segment is required for the induction of autoantibodies against thyroglobulin.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2177724-1081228, http://linkedlifedata.com/resource/pubmed/commentcorrection/2177724-271999, http://linkedlifedata.com/resource/pubmed/commentcorrection/2177724-2828004, http://linkedlifedata.com/resource/pubmed/commentcorrection/2177724-2982096, http://linkedlifedata.com/resource/pubmed/commentcorrection/2177724-4292248, http://linkedlifedata.com/resource/pubmed/commentcorrection/2177724-4936649, http://linkedlifedata.com/resource/pubmed/commentcorrection/2177724-6265585, http://linkedlifedata.com/resource/pubmed/commentcorrection/2177724-6983610, http://linkedlifedata.com/resource/pubmed/commentcorrection/2177724-6989930, http://linkedlifedata.com/resource/pubmed/commentcorrection/2177724-7032771, http://linkedlifedata.com/resource/pubmed/commentcorrection/2177724-767254, http://linkedlifedata.com/resource/pubmed/commentcorrection/2177724-975252
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0019-2805
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
581-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Anti-thyroglobulin antibodies induced with recombinant reovirus infection in BALB/c mice.
pubmed:affiliation
Laboratory of Immune Cytology, National Institute of Animal Health, Ibaraki, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't