Linked Life Data

21742133

Source:http://linkedlifedata.com/resource/pubmed/id/21742133

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2011-7-11
pubmed:abstractText
A screening method for the analysis of seven anti-viral drugs in poultry tissue has been developed. These include anti-influenza drugs (amantadine, rimantadine, zanamivir and oseltamivir and its carboxylate metabolite), anti-herpes drugs (acyclovir and ganciclovir) and an immunomodulator (imiquimod). Poultry tissue was extracted in acetonitrile:water:acetic acid. After sample purification, using a strong cation exchange column, the eluate was split into two fractions. The first portion was dissolved in methanol:water and the second in acetonitrile:methanol:water. Both fractions were analysed on a zwitterionic hydrophilic interaction liquid chromatography column coupled to a triple quadrupole mass spectrometer. The screening method was successfully validated according to Commission Decision 2002/657/EC in three different laboratories with CC? concentrations of ?10 ?g kg(-1).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1873-4324
pubmed:author
pubmed:copyrightInfo
Crown Copyright © 2010. Published by Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
26
pubmed:volume
700
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
194-200
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Screening method for the analysis of antiviral drugs in poultry tissues using zwitterionic hydrophilic interaction liquid chromatography/tandem mass spectrometry.
pubmed:affiliation
Food and Environment Research Agency, Sand Hutton, York, UK. danny.chan@fera.gsi.gov.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't