Linked Life Data

2174033

Source:http://linkedlifedata.com/resource/pubmed/id/2174033

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
32
pubmed:dateCreated
1991-1-8
pubmed:abstractText
During muscle development, muscle-specific gene expression is achieved by a complex set of transcriptional and post-transcriptional mechanisms. We examined the requirement of new protein synthesis and myogenin expression for muscle-specific tropomyosin expression during myogenesis of the rat muscle cell line L6E9. The results show that new protein synthesis is required for both muscle gene transcription and muscle-specific alternate RNA processing. However, once initiated, the synthesis of muscle tropomyosin mRNA continued in the presence of cycloheximide, while the expression of muscle actin, myosin heavy chain, and myogenin mRNA was abolished. These results suggest that muscle-specific processing of tropomyosin transcripts can continue to occur in the absence of myogenin expression unlike the expression of muscle actin and myosin heavy chain mRNAs. However, the transfection of myogenin cDNA into nonmuscle cells induced muscle-specific RNA processing of tropomyosin, suggesting indirect involvement of myogenic factors in the initiation of muscle-specific RNA processing pathways.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
265
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19381-4
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Muscle-specific RNA processing continues in the absence of myogenin expression.
pubmed:affiliation
Department of Biochemistry & Molecular Biology, M. D. Anderson Cancer Center, University of Texas, Houston 77030.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't