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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1990-8-13
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|
pubmed:abstractText |
Rabbit isolated jugular veins respond to substance P and related neurokinins with concentration-dependent contractions which appears to be due to the activation of a single neurokinin receptor of the NK-1 type. This is demonstrated by the order of potency of neurokinins and some of their fragments as well as by the strong activity of NK-1-selective agonists and the weakness of NK-2- and NK-3-selective agonists. The present results indicate that the rabbit jugular vein provides a sensitive, specific and selective NK-1 preparation which responds directly to neurokinins with contractions and therefore can be useful for characterization of NK-1 agonists and antagonists.
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|
pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0014-2999
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
25
|
|
pubmed:volume |
179
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
457-62
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:2163859-Angiotensin II,
pubmed-meshheading:2163859-Animals,
pubmed-meshheading:2163859-Dogs,
pubmed-meshheading:2163859-Jugular Veins,
pubmed-meshheading:2163859-Muscle, Smooth, Vascular,
pubmed-meshheading:2163859-Muscle Contraction,
pubmed-meshheading:2163859-Neuropeptides,
pubmed-meshheading:2163859-Rabbits,
pubmed-meshheading:2163859-Receptors, Neurokinin-1,
pubmed-meshheading:2163859-Receptors, Neurokinin-2,
pubmed-meshheading:2163859-Receptors, Neurotransmitter
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|
pubmed:year |
1990
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|
pubmed:articleTitle |
The rabbit jugular vein is a contractile NK-1 receptor system.
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|
pubmed:affiliation |
Department of Pharmacology, Medical School, University of Sherbrooke, Québec, Canada.
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|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
