Source:http://linkedlifedata.com/resource/umls/id/C0164209
MSH: A class of cell surface receptors for tachykinins with a preference for substance P. Neurokinin-1 (NK-1) receptors have been cloned and are members of the G protein coupled receptor superfamily. They are found on many cell types including central and peripheral neurons, smooth muscle cells, acinar cells, endothelial cells, fibroblasts, and immune cells.,NCI: Encoded by human TACR1 Gene (GPCR1 Family), 407-aa 46-kDa Tachykinin Receptor 1 is a receptor for the tachykinin neuropeptide substance P and an integral membrane protein with 7 hydrophobic transmembrane regions that probably associates with G proteins that activate a phosphatidylinositol-calcium second messenger system. TACR1 is also involved in mediation of phosphatidylinositol metabolism of substance P. Receptor affinity for tachykinins is: substance P, substance K, neuromedin K. (NCI)