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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4950
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pubmed:dateCreated |
1990-4-27
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pubmed:abstractText |
The ras proto-oncogene products appear to relay intracellular signals via the Ras guanosine triphosphatase (GTPase) activator protein, GAP. In dog epithelial cells expressing human platelet-derived growth factor (PDGF) receptors, binding of PDGF caused approximately one-tenth of the total GAP molecules to complex with the receptor. Studies with mutant PDGF receptors showed that maximum association required both receptor kinase activity and phosphorylatable tyrosine residues at both the identified sites of receptor autophosphorylation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/GTP Phosphohydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/GTPase-Activating Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Protein p21(ras),
http://linkedlifedata.com/resource/pubmed/chemical/Phosphopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/ras GTPase-Activating Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
247
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1578-81
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2157284-Animals,
pubmed-meshheading:2157284-Cells, Cultured,
pubmed-meshheading:2157284-Electrophoresis, Gel, Two-Dimensional,
pubmed-meshheading:2157284-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:2157284-GTP Phosphohydrolases,
pubmed-meshheading:2157284-GTPase-Activating Proteins,
pubmed-meshheading:2157284-Humans,
pubmed-meshheading:2157284-Immunoblotting,
pubmed-meshheading:2157284-Oncogene Protein p21(ras),
pubmed-meshheading:2157284-Peptide Mapping,
pubmed-meshheading:2157284-Phosphopeptides,
pubmed-meshheading:2157284-Phosphorylation,
pubmed-meshheading:2157284-Platelet-Derived Growth Factor,
pubmed-meshheading:2157284-Precipitin Tests,
pubmed-meshheading:2157284-Protein Kinases,
pubmed-meshheading:2157284-Proteins,
pubmed-meshheading:2157284-Receptors, Cell Surface,
pubmed-meshheading:2157284-Receptors, Platelet-Derived Growth Factor,
pubmed-meshheading:2157284-Tyrosine,
pubmed-meshheading:2157284-ras GTPase-Activating Proteins
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pubmed:year |
1990
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pubmed:articleTitle |
Binding of GAP to activated PDGF receptors.
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pubmed:affiliation |
Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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