| pubmed-article:21499231 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21499231 | lifeskim:mentions | umls-concept:C0020981 | lld:lifeskim |
| pubmed-article:21499231 | lifeskim:mentions | umls-concept:C0025250 | lld:lifeskim |
| pubmed-article:21499231 | lifeskim:mentions | umls-concept:C1366499 | lld:lifeskim |
| pubmed-article:21499231 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:21499231 | lifeskim:mentions | umls-concept:C1415846 | lld:lifeskim |
| pubmed-article:21499231 | lifeskim:mentions | umls-concept:C0016263 | lld:lifeskim |
| pubmed-article:21499231 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:21499231 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:21499231 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:21499231 | pubmed:dateCreated | 2011-7-1 | lld:pubmed |
| pubmed-article:21499231 | pubmed:abstractText | Angioimmunoblastic T-cell lymphoma is immunologically defined by the expression of CD10 and the follicular helper T cell (T(FH)) markers such as CXCL13, programmed death-1 (PD-1) and inducible T-cell costimulator (ICOS). This T(FH) profile has been mainly reported by immunohistochemistry. Here, using multiparametric flow cytometry, the relevance of ICOS and PD-1 to angioimmunoblastic T-cell lymphoma diagnosis was evaluated in lymph node (n=15) as well as in peripheral blood (n=13) among a series of 28 angioimmunoblastic T-cell lymphoma cases, in addition to the CD10 expression (available in 26 lymph node and 15 peripheral blood specimens). In this series, CD10 expression was present in 23/26 (88%) lymph node and in 12/15 (80%) peripheral blood cases and ICOS in 13/15 (87%) lymph node and in 6/13 (47%) peripheral blood cases, whereas neither significant CD10 nor ICOS T cells were identified in the control group (lymph nodes with reactive hyperplasia=10, peripheral blood of healthy donors=15). PD-1 expression was less informative as observed in both angioimmunoblastic T-cell lymphoma and control cases. The multiparametric approach allowed us to confirm the frequent blood dissemination in angioimmunoblastic T-cell lymphoma and to show that circulating neoplastic T cells correspond more often to a CD10-positive subset than to an ICOS-positive subset. Consequently, if ICOS constitutes an additional feature for the diagnosis of angioimmunoblastic T-cell lymphoma, it appears less sensitive than CD10 expression for the detection of circulating neoplastic T cells. | lld:pubmed |
| pubmed-article:21499231 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21499231 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21499231 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21499231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21499231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21499231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21499231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21499231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21499231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21499231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21499231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21499231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21499231 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21499231 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21499231 | pubmed:issn | 1530-0285 | lld:pubmed |
| pubmed-article:21499231 | pubmed:author | pubmed-author:BergerFrançoi... | lld:pubmed |
| pubmed-article:21499231 | pubmed:author | pubmed-author:SallesGillesG | lld:pubmed |
| pubmed-article:21499231 | pubmed:author | pubmed-author:MagaudJean-Pi... | lld:pubmed |
| pubmed-article:21499231 | pubmed:author | pubmed-author:BaseggioLucil... | lld:pubmed |
| pubmed-article:21499231 | pubmed:author | pubmed-author:FelmanPascale... | lld:pubmed |
| pubmed-article:21499231 | pubmed:author | pubmed-author:FfrenchMartin... | lld:pubmed |
| pubmed-article:21499231 | pubmed:author | pubmed-author:Traverse-Gleh... | lld:pubmed |
| pubmed-article:21499231 | pubmed:author | pubmed-author:MorelDominiqu... | lld:pubmed |
| pubmed-article:21499231 | pubmed:author | pubmed-author:JalladesLaure... | lld:pubmed |
| pubmed-article:21499231 | pubmed:author | pubmed-author:GoedertGhisla... | lld:pubmed |
| pubmed-article:21499231 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21499231 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:21499231 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21499231 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21499231 | pubmed:pagination | 993-1003 | lld:pubmed |
| pubmed-article:21499231 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:21499231 | pubmed:meshHeading | pubmed-meshheading:21499231... | lld:pubmed |
| pubmed-article:21499231 | pubmed:meshHeading | pubmed-meshheading:21499231... | lld:pubmed |
| pubmed-article:21499231 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21499231 | pubmed:articleTitle | CD10 and ICOS expression by multiparametric flow cytometry in angioimmunoblastic T-cell lymphoma. | lld:pubmed |
| pubmed-article:21499231 | pubmed:affiliation | Laboratoire d'Hématologie Cellulaire, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France. | lld:pubmed |
| pubmed-article:21499231 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:4311 | entrezgene:pubmed | pubmed-article:21499231 | lld:entrezgene |
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| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21499231 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21499231 | lld:entrezgene |
