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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-7-1
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pubmed:abstractText |
Angioimmunoblastic T-cell lymphoma is immunologically defined by the expression of CD10 and the follicular helper T cell (T(FH)) markers such as CXCL13, programmed death-1 (PD-1) and inducible T-cell costimulator (ICOS). This T(FH) profile has been mainly reported by immunohistochemistry. Here, using multiparametric flow cytometry, the relevance of ICOS and PD-1 to angioimmunoblastic T-cell lymphoma diagnosis was evaluated in lymph node (n=15) as well as in peripheral blood (n=13) among a series of 28 angioimmunoblastic T-cell lymphoma cases, in addition to the CD10 expression (available in 26 lymph node and 15 peripheral blood specimens). In this series, CD10 expression was present in 23/26 (88%) lymph node and in 12/15 (80%) peripheral blood cases and ICOS in 13/15 (87%) lymph node and in 6/13 (47%) peripheral blood cases, whereas neither significant CD10 nor ICOS T cells were identified in the control group (lymph nodes with reactive hyperplasia=10, peripheral blood of healthy donors=15). PD-1 expression was less informative as observed in both angioimmunoblastic T-cell lymphoma and control cases. The multiparametric approach allowed us to confirm the frequent blood dissemination in angioimmunoblastic T-cell lymphoma and to show that circulating neoplastic T cells correspond more often to a CD10-positive subset than to an ICOS-positive subset. Consequently, if ICOS constitutes an additional feature for the diagnosis of angioimmunoblastic T-cell lymphoma, it appears less sensitive than CD10 expression for the detection of circulating neoplastic T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ICOS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Inducible T-Cell Co-Stimulator...,
http://linkedlifedata.com/resource/pubmed/chemical/Neprilysin,
http://linkedlifedata.com/resource/pubmed/chemical/PDCD1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1530-0285
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
993-1003
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21499231-Adult,
pubmed-meshheading:21499231-Aged,
pubmed-meshheading:21499231-Aged, 80 and over,
pubmed-meshheading:21499231-Antigens, CD,
pubmed-meshheading:21499231-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:21499231-Apoptosis Regulatory Proteins,
pubmed-meshheading:21499231-Cell Separation,
pubmed-meshheading:21499231-Female,
pubmed-meshheading:21499231-Flow Cytometry,
pubmed-meshheading:21499231-Humans,
pubmed-meshheading:21499231-Immunoblastic Lymphadenopathy,
pubmed-meshheading:21499231-Inducible T-Cell Co-Stimulator Protein,
pubmed-meshheading:21499231-Lymph Nodes,
pubmed-meshheading:21499231-Lymphoma, T-Cell,
pubmed-meshheading:21499231-Male,
pubmed-meshheading:21499231-Middle Aged,
pubmed-meshheading:21499231-Neoplastic Cells, Circulating,
pubmed-meshheading:21499231-Neprilysin,
pubmed-meshheading:21499231-Programmed Cell Death 1 Receptor,
pubmed-meshheading:21499231-Tumor Markers, Biological
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pubmed:year |
2011
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pubmed:articleTitle |
CD10 and ICOS expression by multiparametric flow cytometry in angioimmunoblastic T-cell lymphoma.
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pubmed:affiliation |
Laboratoire d'Hématologie Cellulaire, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
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pubmed:publicationType |
Journal Article
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