Source:http://linkedlifedata.com/resource/pubmed/id/21425122
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2011-8-2
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| pubmed:abstractText |
The origin of the mesenchymal cells responsible for the intimal fibrosis in systemic sclerosis (SSc) has not been fully identified. The present study was undertaken to investigate whether subendothelial mesenchymal cells may emerge through transdifferentiation of endothelial cells (ECs) into myofibroblasts via endothelial-mesenchymal transition (EndoMT) in vitro and to explore the signaling pathways involved in this process.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1529-0131
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 by the American College of Rheumatology.
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| pubmed:issnType |
Electronic
|
| pubmed:volume |
63
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2473-83
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| pubmed:meshHeading |
pubmed-meshheading:21425122-Animals,
pubmed-meshheading:21425122-Cell Transdifferentiation,
pubmed-meshheading:21425122-Cells, Cultured,
pubmed-meshheading:21425122-Endothelial Cells,
pubmed-meshheading:21425122-Mice,
pubmed-meshheading:21425122-Myofibroblasts,
pubmed-meshheading:21425122-Protein Kinase C-delta,
pubmed-meshheading:21425122-Proto-Oncogene Proteins c-abl,
pubmed-meshheading:21425122-Signal Transduction,
pubmed-meshheading:21425122-Transforming Growth Factor beta
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| pubmed:year |
2011
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| pubmed:articleTitle |
Protein kinase C? and c-Abl kinase are required for transforming growth factor ? induction of endothelial-mesenchymal transition in vitro.
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| pubmed:affiliation |
Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|