Source:http://linkedlifedata.com/resource/pubmed/id/21414776
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2011-4-4
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| pubmed:abstractText |
The total asymmetric synthesis of (+)- and (-)-clusianone and (+)- and (-)-clusianone methyl enol ether is reported. Asymmetric induction is achieved through the use of ACC alkylation, providing the key intermediates with an er of 99:1. The four synthetic compounds were evaluated for their anti-HIV activity. Both (+)- and (-)-clusianone displayed significant anti-HIV activity.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1464-3405
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2406-9
|
| pubmed:meshHeading |
pubmed-meshheading:21414776-Alkylation,
pubmed-meshheading:21414776-Anti-HIV Agents,
pubmed-meshheading:21414776-Bicyclo Compounds,
pubmed-meshheading:21414776-Cell Line,
pubmed-meshheading:21414776-Ethers,
pubmed-meshheading:21414776-HIV,
pubmed-meshheading:21414776-Humans,
pubmed-meshheading:21414776-Stereoisomerism
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Asymmetric total synthesis of (+)- and (-)-clusianone and (+)- and (-)-clusianone methyl enol ether via ACC alkylation and evaluation of their anti-HIV activity.
|
| pubmed:affiliation |
Department of Chemistry, Duke University, Durham, NC 27705, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|