Source:http://linkedlifedata.com/resource/umls/id/C0002074
MSH: The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.,CSP: substitution of an alkyl group for an active hydrogen atom in an organic compound.,NCI: Alkylating Activity in biological systems is typically a process of covalent bonding in which a chemical substance replaces hydrogen atom(s) in biologically active molecules with alkyl radical(s), hindering proper function. DNA alkylation results in strand cross-linking and can inhibit DNA replication.