Linked Life Data

21331593

Source:http://linkedlifedata.com/resource/pubmed/id/21331593

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2011-7-11
pubmed:abstractText
This study investigates the differential gene expression profile of JAK2(V617F)-positive myeloproliferative neoplasm (MPN) patients, with and without response to hydroxyurea (HU) treatment. Twenty-one polycythemia vera, 28 essential thrombocythemia, eight secondary erythrocytosis, and 30 controls were studied. Thirty-four genes were overexpressed in patients who did not respond to HU. Of these, some participate in proliferative pathways: MAPK, AKT, Src kinase (SFK), and JAK2 pathway. JAK2 allele burden was similar between groups of responders and nonresponder. A molecular fingerprint distinguishes JAK2(V617F)-positive MPN patients without response to HU treatment, with overexpression of JAK2, MAPK14, PIK3CA, and SFK genes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1432-0584
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
939-46
pubmed:meshHeading
pubmed-meshheading:21331593-Adult, pubmed-meshheading:21331593-Aged, pubmed-meshheading:21331593-Aged, 80 and over, pubmed-meshheading:21331593-Case-Control Studies, pubmed-meshheading:21331593-Female, pubmed-meshheading:21331593-Gene Expression Profiling, pubmed-meshheading:21331593-Gene Expression Regulation, pubmed-meshheading:21331593-Gene Expression Regulation, Neoplastic, pubmed-meshheading:21331593-Humans, pubmed-meshheading:21331593-Hydroxyurea, pubmed-meshheading:21331593-Janus Kinase 2, pubmed-meshheading:21331593-Male, pubmed-meshheading:21331593-Middle Aged, pubmed-meshheading:21331593-Polycythemia, pubmed-meshheading:21331593-Polycythemia Vera, pubmed-meshheading:21331593-Signal Transduction, pubmed-meshheading:21331593-Thrombocythemia, Essential, pubmed-meshheading:21331593-Transcription Factors, pubmed-meshheading:21331593-Young Adult, pubmed-meshheading:21331593-src-Family Kinases
pubmed:year
2011
pubmed:articleTitle
Differential expression of JAK2 and Src kinase genes in response to hydroxyurea treatment in polycythemia vera and essential thrombocythemia.
pubmed:affiliation
Servicio de Hematología, Hospital Universitario 12 de Octubre, Avenida Córdoba s/n, 28041, Madrid, Spain.
pubmed:publicationType
Journal Article