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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-3-3
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pubmed:abstractText |
Sorafenib, a multikinase inhibitor targeting Raf and VEGFR, has shown activity in unselected patients with non-small-cell lung cancer (NSCLC). At present there are no validated biomarkers indicative of sorafenib activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/BRAF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Benzenesulfonates,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/EGFR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/KRAS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins B-raf,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/sorafenib
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:CaoLiangL,
pubmed-author:ChoykePeterP,
pubmed-author:ForceJeremyJ,
pubmed-author:GiacconeGiuseppeG,
pubmed-author:GutierrezMartinM,
pubmed-author:KeenCorrineC,
pubmed-author:KellyRonan JRJ,
pubmed-author:KummarShivaaniS,
pubmed-author:Lopez-ChavezArielA,
pubmed-author:RaffeldMarkM,
pubmed-author:RajanArunA,
pubmed-author:SteinbergSeth MSM,
pubmed-author:TurkbeyBarisB,
pubmed-author:WrightJohn JJJ,
pubmed-author:XiLiqiangL,
pubmed-author:YuYunkaiY
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pubmed:copyrightInfo |
©2011 AACR.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1190-9
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pubmed:meshHeading |
pubmed-meshheading:21224376-Adult,
pubmed-meshheading:21224376-Aged,
pubmed-meshheading:21224376-Aged, 80 and over,
pubmed-meshheading:21224376-Angiogenesis Inhibitors,
pubmed-meshheading:21224376-Antineoplastic Agents,
pubmed-meshheading:21224376-Benzenesulfonates,
pubmed-meshheading:21224376-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:21224376-Cytokines,
pubmed-meshheading:21224376-Disease-Free Survival,
pubmed-meshheading:21224376-Drug Toxicity,
pubmed-meshheading:21224376-Female,
pubmed-meshheading:21224376-Genes, ras,
pubmed-meshheading:21224376-Humans,
pubmed-meshheading:21224376-Lung Neoplasms,
pubmed-meshheading:21224376-Magnetic Resonance Angiography,
pubmed-meshheading:21224376-Male,
pubmed-meshheading:21224376-Middle Aged,
pubmed-meshheading:21224376-Mutation,
pubmed-meshheading:21224376-Neovascularization, Pathologic,
pubmed-meshheading:21224376-Prognosis,
pubmed-meshheading:21224376-Protein Kinase Inhibitors,
pubmed-meshheading:21224376-Proto-Oncogene Proteins,
pubmed-meshheading:21224376-Proto-Oncogene Proteins B-raf,
pubmed-meshheading:21224376-Pyridines,
pubmed-meshheading:21224376-Receptor, Epidermal Growth Factor,
pubmed-meshheading:21224376-Tumor Markers, Biological,
pubmed-meshheading:21224376-ras Proteins
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pubmed:year |
2011
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pubmed:articleTitle |
Evaluation of KRAS mutations, angiogenic biomarkers, and DCE-MRI in patients with advanced non-small-cell lung cancer receiving sorafenib.
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pubmed:affiliation |
Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-1457, USA.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Clinical Trial, Phase II,
Research Support, N.I.H., Intramural
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