Source:http://linkedlifedata.com/resource/umls/id/C1537502
NCI: This gene is involved in signal transduction and apoptosis.,NCI: A gene that may cause cancer when it is mutated (changed). The Kras gene makes the KRAS protein, which is involved in cell signaling pathways, cell growth, and apoptosis (cell death). Agents that block the activity of the mutated Kras gene or its protein may stop the growth of cancer.,NCI: Human Oncogene K-Ras is a mutated variant of KRAS2 Gene, which encodes two alternative isoforms of monomeric p21 K-RAS protein, a monomeric GTPase involved in transmembrane signal transduction that alternates between inactive GDP-bound and active GTP-bound forms. K-Ras is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein. Mitogen-stimulated RAS stabilizes MYC protein and enhances MYC accumulation by the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC. Implicated in a variety of human tumors, mutations of specific amino acids activate RAS to transform cells. KRAS is i