| pubmed-article:2118527 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2118527 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:2118527 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:2118527 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2118527 | lifeskim:mentions | umls-concept:C0032144 | lld:lifeskim |
| pubmed-article:2118527 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:2118527 | lifeskim:mentions | umls-concept:C0014264 | lld:lifeskim |
| pubmed-article:2118527 | lifeskim:mentions | umls-concept:C0030190 | lld:lifeskim |
| pubmed-article:2118527 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2118527 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:2118527 | pubmed:issue | 26 | lld:pubmed |
| pubmed-article:2118527 | pubmed:dateCreated | 1990-10-11 | lld:pubmed |
| pubmed-article:2118527 | pubmed:abstractText | The tissue-specific distribution of tissue-type and urokinase-type plasminogen activator (t-PA and u-PA) and their inhibitor type 1 (PAI-1) was analyzed at mRNA level in five major rat organ tissues. t-PA mRNA was detected in lung, kidney, heart, and liver. u-PA mRNA was detected in kidney and lung. Presence of PA mRNA correlated with the detection of PA activity in extracts of these tissues. PAI-1 mRNA was detected predominantly in heart and lung. Although PAI activity could not be measured directly in tissue extracts, the presence of PAI-1 mRNA correlated with the occurrence of PA.PAI complex in fibrin autography of tissue extracts. Endotoxin injection caused a very large increase in plasma PAI activity. This increase correlated with a marked increase in PAI-1 mRNA in nearly all tissues studied. The increase in PAI-1 mRNA is most pronounced in lung and liver. Endotoxin injection also caused an increased level of t-PA mRNA in heart and kidney, and an increased u-PA mRNA level in kidney. mRNA analysis of freshly isolated and separated subfractionated liver cells showed that the marked increase in PAI-1 mRNA in the liver after endotoxin injection may be due mainly to a strong increase of PAI-1 mRNA in the liver endothelial cells. | lld:pubmed |
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| pubmed-article:2118527 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2118527 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2118527 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2118527 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2118527 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:2118527 | pubmed:author | pubmed-author:GelehrterT... | lld:pubmed |
| pubmed-article:2118527 | pubmed:author | pubmed-author:EmeisJ JJJ | lld:pubmed |
| pubmed-article:2118527 | pubmed:author | pubmed-author:van BerkelT... | lld:pubmed |
| pubmed-article:2118527 | pubmed:author | pubmed-author:VerheijenJ... | lld:pubmed |
| pubmed-article:2118527 | pubmed:author | pubmed-author:KuiperJJ | lld:pubmed |
| pubmed-article:2118527 | pubmed:author | pubmed-author:QuaxP HPH | lld:pubmed |
| pubmed-article:2118527 | pubmed:author | pubmed-author:ZehebRR | lld:pubmed |
| pubmed-article:2118527 | pubmed:author | pubmed-author:van den... | lld:pubmed |
| pubmed-article:2118527 | pubmed:author | pubmed-author:PadroTT | lld:pubmed |
| pubmed-article:2118527 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2118527 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2118527 | pubmed:volume | 265 | lld:pubmed |
| pubmed-article:2118527 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2118527 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2118527 | pubmed:pagination | 15560-3 | lld:pubmed |
| pubmed-article:2118527 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:2118527 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2118527 | pubmed:articleTitle | Endotoxin induction of plasminogen activator and plasminogen activator inhibitor type 1 mRNA in rat tissues in vivo. | lld:pubmed |
| pubmed-article:2118527 | pubmed:affiliation | Gaubius Institute TNO, Leiden, The Netherlands. | lld:pubmed |
| pubmed-article:2118527 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2118527 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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