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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-12-23
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pubmed:abstractText |
Loss of integrity of the epithelial and endothelial barriers is thought to be a prominent feature of ventilator-induced lung injury (VILI). Based on its function in vascular integrity, we hypothesize that the angiopoietin (Ang)-Tie2 system plays a role in the development of VILI. The present study was designed to examine the effects of mechanical ventilation on the Ang-Tie2 system in lung tissue. Moreover, we evaluated whether treatment with Ang-1, a Tie2 receptor agonist, protects against inflammation, vascular leakage and impaired gas exchange induced by mechanical ventilation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e15653
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pubmed:meshHeading |
pubmed-meshheading:21179479-Angiopoietin-1,
pubmed-meshheading:21179479-Animals,
pubmed-meshheading:21179479-Blood Gas Analysis,
pubmed-meshheading:21179479-Granulocytes,
pubmed-meshheading:21179479-Hemodynamics,
pubmed-meshheading:21179479-Humans,
pubmed-meshheading:21179479-Inflammation,
pubmed-meshheading:21179479-Keratinocytes,
pubmed-meshheading:21179479-Lung Injury,
pubmed-meshheading:21179479-Male,
pubmed-meshheading:21179479-Mice,
pubmed-meshheading:21179479-Mice, Inbred C57BL,
pubmed-meshheading:21179479-Phosphorylation,
pubmed-meshheading:21179479-Receptor, TIE-2,
pubmed-meshheading:21179479-Ventilator-Induced Lung Injury
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pubmed:year |
2010
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pubmed:articleTitle |
Angiopoietin-1 treatment reduces inflammation but does not prevent ventilator-induced lung injury.
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pubmed:affiliation |
Laboratory of Neuroimmunology and Developmental Origins of Disease, Department of Pediatric Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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