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| pubmed-article:21165790 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:21165790 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:21165790 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:21165790 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:21165790 | lifeskim:mentions | umls-concept:C0002085 | lld:lifeskim |
| pubmed-article:21165790 | lifeskim:mentions | umls-concept:C0370215 | lld:lifeskim |
| pubmed-article:21165790 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:21165790 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:21165790 | lifeskim:mentions | umls-concept:C1518071 | lld:lifeskim |
| pubmed-article:21165790 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21165790 | pubmed:dateCreated | 2011-2-2 | lld:pubmed |
| pubmed-article:21165790 | pubmed:abstractText | Human immunodeficiency virus type 1 (HIV-1) nef undergoes adaptive evolution in the central nervous system (CNS), reflecting altered requirements for HIV-1 replication in macrophages/microglia and brain-specific immune selection pressures. The role of Nef in HIV-1 neurotropism and pathogenesis of HIV-associated dementia (HAD) is unclear. In this study, we characterized 82 nef alleles cloned from brain, cerebral spinal fluid, spinal cord, and blood/lymphoid tissue-derived HIV-1 isolates from seven subjects with HAD. CNS isolate-derived nef alleles were genetically compartmentalized and had reduced sequence diversity compared to those from lymphoid tissue isolates. Defective nef alleles predominated in a brain-derived isolate from one of the seven subjects (MACS2-br). The ability of Nef to down-modulate CD4 and MHC class 1 (MHC-1) was generally conserved among nef alleles from both CNS and lymphoid tissues. However, the potency of CD4 and MHC-1 down-modulation was variable, which was associated with sequence alterations known to influence these Nef functions. These results suggest that CD4 and MHC-1 down-modulations are highly conserved functions among nef alleles from CNS- and lymphoid tissue-derived HIV-1 isolates that may contribute to viral replication and escape from immune surveillance in the CNS. | lld:pubmed |
| pubmed-article:21165790 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21165790 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21165790 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21165790 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21165790 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21165790 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21165790 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21165790 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:21165790 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21165790 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21165790 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:21165790 | pubmed:issn | 1538-2443 | lld:pubmed |
| pubmed-article:21165790 | pubmed:author | pubmed-author:ChurchillMeli... | lld:pubmed |
| pubmed-article:21165790 | pubmed:author | pubmed-author:GorryPaul RPR | lld:pubmed |
| pubmed-article:21165790 | pubmed:author | pubmed-author:GabuzdaDanaD | lld:pubmed |
| pubmed-article:21165790 | pubmed:author | pubmed-author:WesselinghSte... | lld:pubmed |
| pubmed-article:21165790 | pubmed:author | pubmed-author:CowleyDanielD | lld:pubmed |
| pubmed-article:21165790 | pubmed:author | pubmed-author:ChiavaroliLis... | lld:pubmed |
| pubmed-article:21165790 | pubmed:author | pubmed-author:EllettAnneA | lld:pubmed |
| pubmed-article:21165790 | pubmed:author | pubmed-author:GrayLachlan... | lld:pubmed |
| pubmed-article:21165790 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21165790 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:21165790 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21165790 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21165790 | pubmed:pagination | 82-91 | lld:pubmed |
| pubmed-article:21165790 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
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| pubmed-article:21165790 | pubmed:meshHeading | pubmed-meshheading:21165790... | lld:pubmed |
| pubmed-article:21165790 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21165790 | pubmed:articleTitle | CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates. | lld:pubmed |
| pubmed-article:21165790 | pubmed:affiliation | Center for Virology, Burnet Institute, 85 Commercial Rd, Melbourne, 3004 VIC, Australia. | lld:pubmed |
| pubmed-article:21165790 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21165790 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21165790 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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