Source:http://linkedlifedata.com/resource/entrezgene/interaction/3107-156110
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10366557,
pubmed-article:10684310,
pubmed-article:10707087,
pubmed-article:10982373,
pubmed-article:11289809,
pubmed-article:11463741,
pubmed-article:11578695,
pubmed-article:12414957,
pubmed-article:12526811,
pubmed-article:12734410,
pubmed-article:12836198,
pubmed-article:14965316,
pubmed-article:15078178,
pubmed-article:15638726,
pubmed-article:16091223,
pubmed-article:16272310,
pubmed-article:17170457,
pubmed-article:17581864,
pubmed-article:17586321,
pubmed-article:17632197,
pubmed-article:17632570,
pubmed-article:17878955,
pubmed-article:18005680,
pubmed-article:18005690,
pubmed-article:18057255,
pubmed-article:18296443,
pubmed-article:18438604,
pubmed-article:18653452,
pubmed-article:18725938,
pubmed-article:18808677,
pubmed-article:19149577,
pubmed-article:19449444,
pubmed-article:19555986,
pubmed-article:19643141,
pubmed-article:19770068,
pubmed-article:19847956,
pubmed-article:20012528,
pubmed-article:20380698,
pubmed-article:20594957,
pubmed-article:20702582,
pubmed-article:21068258,
pubmed-article:21165790,
pubmed-article:21209113,
pubmed-article:21482738,
pubmed-article:21543478,
pubmed-article:21762823,
pubmed-article:21861776,
pubmed-article:21896007,
pubmed-article:22103831,
pubmed-article:22103833,
pubmed-article:22103834,
pubmed-article:22175768,
pubmed-article:22301137,
pubmed-article:22301152,
pubmed-article:22537596,
pubmed-article:22553319,
pubmed-article:22651890,
pubmed-article:22705789,
pubmed-article:22767237,
pubmed-article:22826228,
pubmed-article:22844345,
pubmed-article:8612235,
pubmed-article:9052838,
pubmed-article:9582271,
pubmed-article:9586638
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
A methionine residue at amino acid 20 in the alpha-helix domain is required for the ability of HIV-1 Nef to downregulate MHC-I expression but not for the downregulation of CD4,
Amino acid residue Y320 in the MHC-I cytoplasmic domain and residues E62-65 and P78 in HIV-1 Nef are required for interaction with the mu subunit of AP-1,
Asp327 and Tyr320 of MHC-I, Asp123 of Nef, and Arg225, Arg393, Lys396, Arg211, and Arg246 of mu 1 are involved in a crucial three-way electrostatic network, which results in the Nef-MHC-I CD-mu 1 complex formation,
Deletion of the 19 N-terminal amino acids including the myristoylation signal from HIV-1 Nef inhibits both MHC-I and CD4 downregulation while preserving most CTL, T-helper and B-cell epitopes,
Double (W13A/V16R) and triple (W13A/V16R/M20A) substitution mutants of HIV-1 Nef fail to downregulate MHC-I,
Four glutamic acids from position 62 to 65 in the SH3 domain of HIV-1 Nef bind to the cytoplasmic tail at position 320Y of MHC-I, and are required for the Nef-mediated downregulation of MHC-I from the cell surface,
HIV-1 Nef downregulates expression of MHC-I by blocking transport of MHC-I molecules to the cell surface through a mechanism that requires phosphoinositide 3-kinase (PI 3-kinase) activity,
HIV-1 Nef downregulates the expression of MHC-I at the surface of lymphoid, monocytic and epithelial cells, causing MHC-I molecules to be rapidly internalized, accumulated in endosomal vesicles and degraded,
HIV-1 Nef with A84D, Y135F, and G140R mutation impairs to its ability to downregulate MHC-I,
HIV-1 Nef-induced downregulation of MHC-I expression and MHC-I targeting to the trans-Golgi network (TGN) require the binding of Nef to PACS-1, a molecule that controls the TGN localization of the cellular protein furin,
HIV-1 Nef-mediated downregulation of MHC-I requires Nef motif EEEE(65)-dependent binding to the sorting protein PACS-2, which targets Nef to the paranuclear region and enables Nef PXXP(75) to bind and activate a trans-Golgi network localized Src kinase,
HLA-A2 molecules with HLA-A cytoplasmic domains are more downregulated by HIV-1 Nef than those with HLA-B domains. There is no downregulation of HLA-A2 with HLA-C cytoplasmic domains by Nef,
In promonocytic cells, Nef/Hck recruits the ZAP-70 homolog Syk to downregulate MHC-I,
Interaction of HIV-1 Nef with the mu subunit of AP adaptor complexes requires the recognition of tyrosine-based sorting signals, which likely facilitates the connection between MHC I and the clathrin-dependent sorting machinery,
MHC-I is found in the Rab7(+) vesicles and is targeted for degradation via the activity of the Nef-interacting protein, beta-COP,
Nef/Hck complex recruits and phosphorylates the tyrosine kinase ZAP-70, which binds class I PI3K to trigger MHC-I downregulation in primary CD4+ T cells,
Protective HLA alleles have a true preference for HIV-1 Gag protein, while non-protective HLA alleles preferentially target HIV-1 Nef,
The HIV-1 Nef highly conserved valine-glycine-phenylalanine amino acid triplet (VGF) motif, which links the acidic cluster and the proline-rich motif, is important for downregulation of CXCR4 and MHC-I
|
| entrezgene:keyphrase |
downregulates,
interacts with,
binds,
complexes with,
degrades,
targeted by
|