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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-3-1
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pubmed:abstractText |
Enhanced platelet activation in human immunodeficiency virus (HIV)-1-infected patients has been reported and shown to strongly correlate with plasma viral load. Activated platelets are known to express and to release a variety of proteins that can modulate the immune system. Specifically, platelet-derived CD154 has been shown to be directly involved in the development of autoimmune thrombocytopenia (ITP). The mechanism by which HIV-1 infection leads to platelet activation and the effect of this activation on the development of HIV-1 ITP, however, is not fully understood.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1538-7836
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pubmed:author |
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pubmed:copyrightInfo |
© 2011 International Society on Thrombosis and Haemostasis.
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
562-73
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pubmed:meshHeading |
pubmed-meshheading:21143381-Animals,
pubmed-meshheading:21143381-B-Lymphocytes,
pubmed-meshheading:21143381-Blood Platelets,
pubmed-meshheading:21143381-CD40 Ligand,
pubmed-meshheading:21143381-Calcium Signaling,
pubmed-meshheading:21143381-Cell Line,
pubmed-meshheading:21143381-Cell-Derived Microparticles,
pubmed-meshheading:21143381-Cyclic AMP,
pubmed-meshheading:21143381-Genes, tat,
pubmed-meshheading:21143381-HIV Infections,
pubmed-meshheading:21143381-HIV-1,
pubmed-meshheading:21143381-Humans,
pubmed-meshheading:21143381-Integrin beta3,
pubmed-meshheading:21143381-Mice,
pubmed-meshheading:21143381-Mice, Inbred BALB C,
pubmed-meshheading:21143381-Mice, Knockout,
pubmed-meshheading:21143381-Microscopy, Electron, Transmission,
pubmed-meshheading:21143381-Models, Biological,
pubmed-meshheading:21143381-Platelet Activation,
pubmed-meshheading:21143381-Purpura, Thrombocytopenic, Idiopathic,
pubmed-meshheading:21143381-Receptors, CCR3,
pubmed-meshheading:21143381-Transfection,
pubmed-meshheading:21143381-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2011
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pubmed:articleTitle |
HIV-1 Tat-induced platelet activation and release of CD154 contribute to HIV-1-associated autoimmune thrombocytopenia.
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pubmed:affiliation |
Department of Medicine, NYU Cancer Institute, New York, NY 10016, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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