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rdf:type |
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lifeskim:mentions |
umls-concept:C0030705,
umls-concept:C0205179,
umls-concept:C0282461,
umls-concept:C0302523,
umls-concept:C0518214,
umls-concept:C0684249,
umls-concept:C0700325,
umls-concept:C0936012,
umls-concept:C1514496,
umls-concept:C1517927,
umls-concept:C1707455
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pubmed:issue |
3
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pubmed:dateCreated |
2011-1-19
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pubmed:abstractText |
There are scant data regarding the effects of prophylactic cranial irradiation (PCI) on neurocognitive function (NCF) and quality of life (QOL). Radiation Therapy Oncology Group trial 0214 showed no overall survival (OS) benefit for PCI in stage III non-small-cell lung cancer (NSCLC) at 1 year. However, there was a significant decrease in brain metastases (BM). This analysis focuses on the impact of PCI on NCF and QOL.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1527-7755
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pubmed:author |
pubmed-author:BaeKyounghwaK,
pubmed-author:BogartJeffery AJA,
pubmed-author:BonnerJames AJA,
pubmed-author:ChoyHakH,
pubmed-author:GasparLaurie ELE,
pubmed-author:GoreElizabeth MEM,
pubmed-author:MeyersChristina ACA,
pubmed-author:MovsasBenjaminB,
pubmed-author:SchildSteven ESE,
pubmed-author:SunAlexanderA,
pubmed-author:Werner-WasikMariaM,
pubmed-author:WongStuart JSJ
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pubmed:issnType |
Electronic
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pubmed:day |
20
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pubmed:volume |
29
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
279-86
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pubmed:dateRevised |
2011-3-30
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pubmed:meshHeading |
pubmed-meshheading:21135267-Adult,
pubmed-meshheading:21135267-Aged,
pubmed-meshheading:21135267-Aged, 80 and over,
pubmed-meshheading:21135267-Brain Neoplasms,
pubmed-meshheading:21135267-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:21135267-Cognition,
pubmed-meshheading:21135267-Cognition Disorders,
pubmed-meshheading:21135267-Cranial Irradiation,
pubmed-meshheading:21135267-Female,
pubmed-meshheading:21135267-Humans,
pubmed-meshheading:21135267-Lung Neoplasms,
pubmed-meshheading:21135267-Male,
pubmed-meshheading:21135267-Memory Disorders,
pubmed-meshheading:21135267-Middle Aged,
pubmed-meshheading:21135267-Neuropsychological Tests,
pubmed-meshheading:21135267-Prospective Studies,
pubmed-meshheading:21135267-Quality of Life
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pubmed:year |
2011
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pubmed:articleTitle |
Phase III trial of prophylactic cranial irradiation compared with observation in patients with locally advanced non-small-cell lung cancer: neurocognitive and quality-of-life analysis.
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pubmed:affiliation |
Princess Margaret Hospital-University Health Network, University of Toronto, 610 University Ave, Toronto, Ontario, Canada, M5G 2M9. alex.sun@rmp.uhn.on.ca
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Clinical Trial, Phase III
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