Linked Life Data

20865242

Source:http://linkedlifedata.com/resource/pubmed/id/20865242

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-10-11
pubmed:abstractText
The study reports residues of diclofenac, a non-steroidal anti inflammatory drug, in tissues of 11 White-backed Vulture, Gyps bengalensis collected between 2005 and 2007 and blood plasma of 12 White-backed Vulture, four Egyptian Vulture, Neophron percnopterus and two Griffon Vulture, Gyps fulvus collected during 2005. Samples were analysed using High Performance Liquid Chromatograhy (HPLC) equipped with UV detector. One of the White-backed Vultures collected during 2005 had substantial urate deposits on its viscera and diclofenac was detected in its liver (1.42 ppm wet weight) and kidney (1.18 ppm wet weight), which is suggestive of diclofenac exposure and intoxication. Although uric acid crystals were not observed in the remaining birds received during 2005, the residues of diclofenac detected were at levels higher than the toxic limits (0.25-1 ppm). No residues were detected in any of the tissues of birds collected during 2006 and 2007 (6 birds). About 89% (16 of 18) of plasma samples collected during 2005 had diclofenac residues (White-backed vulture: BDL to 0.17 ppm; Egyptian vulture: BDL to 0.09 ppm; Griffon vulture: 0.07-0.14 ppm). However, plasma diclofenac concentrations were less than the concentrations reported to be toxic. Although use of diclofenac for treating cattle has been banned in India, regular monitoring is recommended to assess the effectiveness of the ban on the drug in support of the conservation of these species.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1432-0800
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
377-80
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Diclofenac residues in blood plasma and tissues of vultures collected from Ahmedabad, India.
pubmed:affiliation
Sálim Ali Centre for Ornithology and Natural History, Coimbatore, India. ecot_mur@yahoo.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't