Linked Life Data

20844260

Source:http://linkedlifedata.com/resource/pubmed/id/20844260

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-11-3
pubmed:abstractText
Obesity of women at conception is increasing, a condition associated with offspring obesity. We hypothesized that maternal obesity increases placental fatty acid transporter (FATP) expression, enhancing delivery of fatty acids to their fetuses. Sheep are a commonly utilized biomedical model for pregnancy studies. Nonpregnant ewes were randomly assigned to a control group [100% of National Research Council (NRC) recommendations] or obese group (OB, 150% of NRC) from 60 days before conception to 75 or 135 days of gestation (dG; term = 150 dG), when placental cotyledonary tissue was collected for analysis. Fetuses of OB ewes were markedly heavier (P < 0.05) on 75 dG than fetuses from control ewes, but this difference disappeared by 135 dG. Maternal obesity markedly increased (P < 0.05) cholesterol and triglyceride concentrations of both maternal and fetal blood. There is no difference in lipoprotein lipase mRNA expression between control and OB group at either gestational age. On 75 dG, the mRNA expression of FATP1 (P < 0.05), FATP4 (P = 0.08), and fatty acid translocase CD (cluster of differentiation) 36 (P < 0.05) proteins were more enhanced in cotyledonary tissue from OB than control ewes; consistently, protein expression of FATP1 and FATP4 was increased (P < 0.05). Similarly, on 135 dG, the mRNA levels of FATP1, FATP4, and CD36 were all higher (P < 0.05), but only FATP4 protein content was enhanced (P < 0.05) in OB cotyledonary tissue. Peroxisome proliferator-activated receptor (PPAR)-? regulates the expression of FATPs. Both the mRNA expression and protein content of PPAR? were increased in OB cotyledonary in the midgestation. In conclusion, maternal obesity enhances the mRNA expression and protein content of FATPs in cotyledonary in the midgestation, which is associated with higher PPAR? content in cotyledonary.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1522-1490
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
299
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R1224-31
pubmed:dateRevised
2011-11-1
pubmed:meshHeading
pubmed-meshheading:20844260-Animal Nutritional Physiological Phenomena, pubmed-meshheading:20844260-Animals, pubmed-meshheading:20844260-Antigens, CD36, pubmed-meshheading:20844260-Cholesterol, pubmed-meshheading:20844260-Fatty Acid Transport Proteins, pubmed-meshheading:20844260-Female, pubmed-meshheading:20844260-Fetal Blood, pubmed-meshheading:20844260-Fetal Weight, pubmed-meshheading:20844260-Gene Expression Regulation, pubmed-meshheading:20844260-Gestational Age, pubmed-meshheading:20844260-Lipoprotein Lipase, pubmed-meshheading:20844260-Maternal Nutritional Physiological Phenomena, pubmed-meshheading:20844260-Obesity, pubmed-meshheading:20844260-PPAR gamma, pubmed-meshheading:20844260-Placenta, pubmed-meshheading:20844260-Pregnancy, pubmed-meshheading:20844260-RNA, Messenger, pubmed-meshheading:20844260-Sheep, pubmed-meshheading:20844260-Triglycerides, pubmed-meshheading:20844260-p38 Mitogen-Activated Protein Kinases
pubmed:year
2010
pubmed:articleTitle
Maternal obesity markedly increases placental fatty acid transporter expression and fetal blood triglycerides at midgestation in the ewe.
pubmed:affiliation
Dept. of Animal Science, Univ. of Wyoming, Laramie, WY 82071, USA. meijun@uwyo.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural