Linked Life Data

20807370

Source:http://linkedlifedata.com/resource/pubmed/id/20807370

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-3-7
pubmed:abstractText
Lutein and zeaxanthin cannot be synthesized de novo in humans, and although lutein is abundant in fruit and vegetables, good dietary sources of zeaxanthin are scarce. Certain corn varieties provide adequate amounts because the ratio of endosperm ?:? lycopene cyclase activity favours the ?-carotene/zeaxanthin branch of the carotenoid pathway. We previously described a transgenic corn line expressing the early enzymes in the pathway (including lycopene ?-cyclase) and therefore accumulating extraordinary levels of ?-carotene. Here, we demonstrate that introgressing the transgenic mini-pathway into wild-type yellow endosperm varieties gives rise to hybrids in which the ?:? ratio is altered additively. Where the ?:? ratio in the genetic background is high, introgression of the mini-pathway allows zeaxanthin production at an unprecedented 56 ?g/g dry weight. This result shows that metabolic synergy between endogenous and heterologous pathways can be used to enhance the levels of nutritionally important metabolites.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1467-7652
pubmed:author
pubmed:copyrightInfo
© 2010 The Authors. Plant Biotechnology Journal © 2010 Society for Experimental Biology, Association of Applied Biologists and Blackwell Publishing Ltd.
pubmed:issnType
Electronic
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
384-93
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Synergistic metabolism in hybrid corn indicates bottlenecks in the carotenoid pathway and leads to the accumulation of extraordinary levels of the nutritionally important carotenoid zeaxanthin.
pubmed:affiliation
Departament de Produccio Vegetal I Ciencia Forestal, University of Lleida, Lleida, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't