Linked Life Data

20687137

Source:http://linkedlifedata.com/resource/pubmed/id/20687137

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-2-25
pubmed:abstractText
Pro-inflammatory cytokine-mediated expression of cell surface adhesion molecules plays a key role in endothelial cell injury, leading to vascular inflammation and the development of many cerebrovascular diseases. Thus, antiinflammatory agents targeting these adhesion molecules may represent potential drugs for the prevention and treatment of cerebrovascular diseases. The present study explored the effects of tanshinone IIA (Tan IIA), an active ingredient present in the Salvia miltiorrhiza root, on the expression of cellular adhesion molecules in TNF-?-stimulated brain microvascular endothelial cells (BMVECs). Treatment with Tan IIA was found to suppress the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), resulting in inhibition of TNF-?-induced adhesion of neutrophils to BMVECs in a dose-dependent manner. In addition, Tan IIA significantly inhibited TNF-?-induced production of reactive oxygen species (ROS), which was accompanied by decreased malondialdehyde (MDA) levels. Treatment with Tan IIA also inhibited nuclear factor-kappa B (NF-?B) activation. Together, these results suggest that Tan IIA regulates TNF-?-induced expression of VCAM-1 and ICAM-1 through inhibition of NF-?B activation and ROS generation in BMVECs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1099-1573
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 John Wiley & Sons, Ltd.
pubmed:issnType
Electronic
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
376-80
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Regulation of adhesion molecules expression in TNF-?-stimulated brain microvascular endothelial cells by tanshinone IIA: involvement of NF-?B and ROS generation.
pubmed:affiliation
Department of Neurosurgery, The General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, PR China. tangchao314159@yahoo.com.cn
pubmed:publicationType
Journal Article