Linked Life Data

20676130

Source:http://linkedlifedata.com/resource/pubmed/id/20676130

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
40
pubmed:dateCreated
2010-10-7
pubmed:abstractText
Transforming growth factor beta (TGF?) is a key regulator of epithelial cell proliferation, immune function and angiogenesis. Because TGF? signaling maintains epithelial homeostasis, dysregulated TGF? signaling is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Defective TGF? signaling in epithelial cells causes hyperproliferation, reduced apoptosis and increased genomic instability, and the compensatory increase in TGF? production by tumor epithelial cells with TGF? signaling defects further promotes tumor growth and metastases by increasing angiogenesis and inflammation in tumor stromal cells. Here, we review the mouse models that we used to study TGF? signaling in HNSCC.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1476-5594
pubmed:author
pubmed:issnType
Electronic
pubmed:day
7
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5437-46
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
TGF? signaling in head and neck squamous cell carcinoma.
pubmed:affiliation
Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, OR, USA.
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural