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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-12-20
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pubmed:abstractText |
This report aims to more accurately define the frequency of the involvement of SRC Family Kinases (SFKs) in imatinib- and dasatinib-resistant CML patients. Clinical samples were analysed during in vivo treatment. We confirmed the high frequency of SFKs involvement in Tyrosine kinase inhibitor-resistant CML (52% of the cases) and even further in progressive disease and blast crises (60% of the cases). The SFKs deregulation is also observed in patients harboring BCR-ABL mutations. In T315I and F317L mutated patients, CML-resistance appears to be promoted by SFKs kinase protein reactivation once the BCR-ABL mutated clone has decreased on Omacetaxine.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1873-5835
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
38-43
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pubmed:meshHeading |
pubmed-meshheading:20673586-Antineoplastic Agents,
pubmed-meshheading:20673586-Base Sequence,
pubmed-meshheading:20673586-Cell Line, Tumor,
pubmed-meshheading:20673586-DNA Primers,
pubmed-meshheading:20673586-Drug Resistance, Neoplasm,
pubmed-meshheading:20673586-Fusion Proteins, bcr-abl,
pubmed-meshheading:20673586-Humans,
pubmed-meshheading:20673586-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:20673586-Longitudinal Studies,
pubmed-meshheading:20673586-Piperazines,
pubmed-meshheading:20673586-Pyrimidines,
pubmed-meshheading:20673586-Thiazoles,
pubmed-meshheading:20673586-src-Family Kinases
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pubmed:year |
2011
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pubmed:articleTitle |
Longitudinal studies of SRC family kinases in imatinib- and dasatinib-resistant chronic myelogenous leukemia patients.
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pubmed:affiliation |
Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Laboratory for Molecular Biology and UMR5239 CNRS, Pierre-Bénite, France. sandrine.hayette@chu-lyon.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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